Article
The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).
The Journal of biological chemistry - 16 Aug 2013
Sussman Robyn T, Stanek Timothy J, Esteso Paul, Gearhart John D, Knudsen Karen E, McMahon Steven B
Abstract excerpt
Pluripotent embryonic stem cells (ESCs) undergo self-renewal until stimulated to differentiate along specific lineage pathways. Many of the transcriptional networks that drive reprogramming of a self-renewing ESC to a differentiating cell have been identified. However, fundamental questions remain unanswered about the epigenetic programs that control these changes in gene expression. Here we report that the...
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