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Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells

1 Mar 2019

Abstract excerpt

The transcription factor BTB and CNC homology 1 (Bach1) is expressed in the embryos of mice, but whether Bach1 regulates the self-renewal and early differentiation of human embryonic stem cells (hESCs) is unknown. We report that the deubiquitinase ubiquitin-specific processing protease 7 (Usp7) is a direct target of Bach1, that Bach1 interacts with Nanog, Sox2, and Oct4, and that Bach1 facilitates their...

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PMID: 30891497
DOI: 10.1126/sciadv.aau7887

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