Article

Therapy-Induced Senescence Shapes Extracellular Matrix Niches and Fibroblast Function in Head and Neck Squamous Cell Carcinoma

2026-02-28

Abstract excerpt

Cellular senescence is a stress-induced state characterised by durable proliferative arrest and extensive transcriptional and secretory reprogramming. In cancer, senescence can suppress early tumour outgrowth, yet persistence of senescent cells and their senescence-associated secretory phenotype (SASP) may drive maladaptive inflammation, immune dysfunction, vascular perturbation and extracellular matrix (ECM) remo...

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Literature Corpus work: 8b3c8213-d390-5427-8185-8eb7c00f21e5
DOI: 10.20944/preprints202602.1499.v1

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