Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.

doi:10.18632/aging.101127

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Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.

Aging - 15 Dec 2016

Mellone Massimiliano, Hanley Christopher J, Thirdborough Steve, Mellows Toby, Garcia Edwin, Woo Jeongmin, Tod Joanne, Frampton Steve, Jenei Veronika, Moutasim Karwan A, Kabir Tasnuva D, Brennan Peter A, Venturi Giulia, Ford Kirsty, Herranz Nicolas, Lim Kue Peng, Clarke James, Lambert Daniel W, Prime Stephen S, Underwood Timothy J, Vijayanand Pandurangan, Eliceiri Kevin W, Woelk Christopher, King Emma V, Gil Jesus, Ottensmeier Christian H, Thomas Gareth J

Abstract excerpt

Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two. Analysis of CAF cultured ex vivo, showed that senescent CAF are predominantly SMA-positive; this was confirmed by...

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PMID: 27992856
DOI: 10.18632/aging.101127
PMCID: PMC5310659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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