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Article

Fibroblast activation and senescence in oral cancer

30 May 2016

Abstract excerpt

There is now compelling evidence that the tumour stroma plays an important role in the pathogenesis of cancers of epithelial origin. The pre-eminent cell type of the stroma is carcinoma-associated fibroblasts. These cells demonstrate remarkable heterogeneity with activation and senescence being common stress responses. In this review, we summarise the part that these cells play in cancer, particularly oral...

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Identifiers

PMID: 27237745
DOI: 10.1111/jop.12456

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