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Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma

25 Aug 2025

Abstract excerpt

BACKGROUND: Cellular senescence plays a significant role in tumorigenesis and tumor progression. Substantial evidence indicates that senescence occurs in cancer-associated fibroblasts (CAFs), the predominant stromal component within the tumor microenvironment (TME), which profoundly impacts tumor biology. However, despite growing evidence of stromal cell involvement in cancer progression, the specific mechanisms...

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PMID: 40855439
DOI: 10.1186/s12964-025-02369-8

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