Article
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state.
Cell reports - 28 Mar 2023
Matsuda Satoru, Revandkar Ajinkya, Dubash Taronish D, Ravi Arvind, Wittner Ben S, Lin Maoxuan, Morris Robert, Burr Risa, Guo Hongshan, Seeger Karsen, Szabolcs Annamaria, Che Dante, Nieman Linda, Getz Gad A, Ting David T, Lawrence Michael S, Gainor Justin, Haber Daniel A, Maheswaran Shyamala
Abstract excerpt
TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence immune checkpoint inhibitor (ICI) responses are unknown. We show that TGF-β induces a deeper senescent state under hypoxia than under normoxia; deep senescence correlates...
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