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Aging and oral squamous cell carcinoma development: the role of cellular senescence

12 Oct 2023

Abstract excerpt

The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype (SASP), which significantly contributes to a spectrum of age-related disorders, including cancer. In the context of carcinogenesis, the SASP produced by senescent...

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PMID: 37904749
DOI: 10.3389/froh.2023.1285276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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