Article

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

2019-11-26

Abstract excerpt

In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB)-zinc finger proteins (KZFPs). Many TEeRS are subsequently coopted in transcription networks, but how KZFPs influence this process is largely unknown. We identify ZNF417 and ZNF587 as primate-specific KZFPs repressing HERVK (human endogenous retrovirus K) and SVA (SINE-VNTR-Al...

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Literature Corpus work: a7628cfc-3e7e-5247-b91a-c6784ecf0456
DOI: 10.1101/856005

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