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A human-specific structural variation at the <i>ZNF558</i> locus controls a gene regulatory network during forebrain development

2020-08-18

Abstract excerpt

The human forebrain has expanded in size and complexity compared to that of chimpanzee despite limited changes in protein-coding genes, suggesting that gene regulation is an important driver of brain evolution. Here we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 transposons but has been c...

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Identifiers and source

Literature Corpus work
09c2c3b5-88bf-57fb-af5e-99a85f4ca0c5
DOI
10.1101/2020.08.18.255562
Open publication

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A human-specific structural variation at the <i>ZNF558</i> locus controls a gene regulatory network during forebrain developmentDOI 10.1101/2020.08.18.255562
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