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The TALE never ends: A comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects.

Human mutation - 1 Sept 2022

Mary Laura, Leclerc Delphine, Gilot David, Belaud-Rotureau Marc-Antoine, Jaillard Sylvie

Abstract excerpt

PBX1 is a highly conserved atypical homeodomain transcription factor (TF) belonging to the TALE (three amino acid loop extension) family. Dimerized with other TALE proteins, it can interact with numerous partners and reach dozens of regulating sequences, suggesting its role as a pioneer factor. PBX1 is expressed throughout the embryonic stages (as early as the blastula stage) in vertebrates. In human, PBX1...

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Epigenetics and DNA Methylation
Gene Expression Regulation, Developmental
Homeodomain Proteins
Phenotype
Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Urological Disorders and Treatments

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PMID: 35451537
DOI: 10.1002/humu.24388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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The TALE never ends: A comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects.PMID 35451537Read ↗

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