Article

KZFP-mediated variable DNA methylation of a primate-specific transposon is linked to type I diabetes in humans

2025-04-22

Abstract excerpt

Variable DNA methylation states during early embryonic development overlap with mechanisms of transposon silencing by Krüppel-associated box zinc finger proteins (KZFPs). We investigated the influence of genetic variation in KZFPs and their transposon targets and identified a variably methylated region (VMR) proximal to the human LY6S-AS1 gene linked to an intronic MER11C retrotransposon targeted by the primate-sp...

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Literature Corpus work: 893d01a7-39c5-5cf0-935c-e9ce676cc20d
DOI: 10.1101/2025.04.22.25326054

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