Article
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood - 1 May 1992
Sugimoto K, Toyoshima H, Sakai R, Miyagawa K, Hagiwara K, Ishikawa F, Takaku F, Yazaki Y, Hirai H
Abstract excerpt
The p53 gene is currently considered to function as a tumor-suppressor gene in various human malignancies. In hematologic malignancies, alterations in the p53 gene have been shown in some human leukemias and lymphomas. Although mutations in the p53 gene are infrequent in acute myelogenous leukemia (AML) patients, we show in this report that alterations in the p53 gene are frequent in myeloid leukemia cell lines....
Topics
- Base Sequence
- Blotting, Southern
- Genes, p53
- Humans
- Leukemia, Myeloid
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Tumor Cells, Cultured