Article

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

2024-02-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND & AIMS</h4> Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recent studies have shown that pancreatic precancer is characterized by a transcriptomic program similar to gastric metaplasia. The aims of this study were to assay IPMN for pyloric markers, to identify molecular drivers, and to de...

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Literature Corpus work: 8b26c778-a9a5-5106-b117-38473b7350cb
DOI: 10.1101/2024.02.25.581948

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