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Article

Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Mar 2023

Liu Zhu, Hong Lian-Lian, Zheng Jin-Sen, Ling Zhe-Nan, Zhang Zhi-Long, Qi Ya-Nan, Zhang Xin-Yu, Zhu Tian-Yu, Wang Jiu-Li, Han Jing, Chen Xiang-Liu, Yu Qi-Ming, Wang Shi, Li Pei, Ling Zhi-Qiang

Abstract excerpt

BACKGROUND: Primary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined. METHODS: We subjected 10 tumor-normal tissue pairs to whole exome sequencing (WES) and whole transcriptome sequencing (WTS). 10 tumor samples were all GLP which involves 100% of the gastric wall...

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Identifiers

PMID: 36450891
DOI: 10.1007/s10120-022-01353-2
PMCID: PMC9950178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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