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Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis

18 Mar 2020

Abstract excerpt

BACKGROUND: Several reports have shown the role of glycosylation in pancreatic cancer (PC), but a global systematic screening of specific glycosyltransferases (glycoTs) in its progression remains unknown. METHODS: We demonstrate a rigorous top-down approach using TCGA-based RNA-Seq analysis, multi-step validation using RT-qPCR, immunoblots and immunohistochemistry. We identified six unique glycoTs (B3GNT3,...

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PMID: 32203219
DOI: 10.1038/s41416-020-0772-3

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