Article
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.
Cell reports - 23 Dec 2025
Quoc-Huy Trinh Vincent, Ankenbauer Katherine E, Torbit Sabrina M, Taranto Christopher P, Liu Jiayue, Batardiere Maelle, Kumar Bhoj, Maurer H Carlo, Revetta Frank, Chen Zhengyi, Kruse Angela R S, Judd Audra M, Copeland Celina, Wong Jahg, Ben-Levy Olivia, Jarvis Brenda, Brown Monica, Brown Jeffrey W, Das Koushik, Makino Yuki, Spraggins Jeffrey M, Lau Ken S, Azadi Parastoo, Maitra Anirban, Tan Marcus C B, DelGiorno Kathleen E
Abstract excerpt
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Although ∼90% of IPMNs are detected before PDAC forms, markers distinguishing benign from malignant disease are lacking, resulting in an abundance of unnecessary, invasive surgeries. Recent studies show that pancreatic precancer assumes a...
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