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Article

Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer.

Advances in experimental medicine and biology - 1 Jan 2022

Patel Jaymin M, Jeselsohn Rinath M

Abstract excerpt

The estrogen receptor alpha (ERα) is a nuclear transcription factor that is expressed in more than 70% of all breast cancers. Key genes involved in proliferation and tumor progression are transcriptionally regulated by ERα making it an important therapeutic target. Indeed, the first class of targeted treatments in cancer are endocrine treatments that target ERα either by competitive inhibition, reduced ligand...

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PMID: 36107319
DOI: 10.1007/978-3-031-11836-4_10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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