Article

Paracrine Bone-Derived Senescent Secretome Induces Spatially Patterned ECM and Biomechanical Vulnerability in Human Brain Organoids

2025-08-13

Abstract excerpt

Aging is increasingly recognized as a systemic process, yet the mechanisms by which senescent cells’ signal from peripheral tissues accelerate brain aging remain poorly defined. Here, we used chronic exposure of human cerebral organoids to the secretome of senescent osteocytes to investigate how peripheral aging signals reshape brain tissue architecture. We combined spatially resolved optical fiber-based interfero...

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Literature Corpus work: 8b182a47-21a6-5201-9385-48db7067f062
DOI: 10.1101/2025.08.11.669674

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