Article

SERPINE1–AP2A1 interplay links substrate stiffness to fibroblast senescence

2026-07-01

Abstract excerpt

Cellular senescence is characterized by stable cell-cycle arrest, cytoskeletal remodeling, and altered secretion of senescence-associated secretory phenotype (SASP) factors, including SERPINE1/plasminogen activator inhibitor-1 (PAI-1). Although extracellular matrix (ECM) stiffening has been linked to fibroblast mechanotransduction and SERPINE1-associated remodeling, the molecular pathway connecting substrate stiff...

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Literature Corpus work: fe3789e6-615e-5ecf-b8c5-7f1a3671b5bc
DOI: 10.64898/2026.06.30.735455

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