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Klotho inhibits neuronal senescence in human brain organoids

2 Aug 2021

Abstract excerpt

Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of the brain. KL exerts potent anti-aging effects on multiple cell types in the body but its role in human brain cells remains largely unclear. Here we show that human cortical neurons, derived from human pluripotent stem cells in 2D cultures or...

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PMID: 34341344
DOI: 10.1038/s41514-021-00070-x

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