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Tracing Cellular Senescence in Bone: Time‐Dependent Changes in Osteocyte Cytoskeleton Mechanics and Morphology

3 Mar 2025

Abstract excerpt

Aging-related bone loss significantly impacts the growing elderly population globally, leading to debilitating conditions such as osteoporosis. Senescent osteocytes play a crucial role in the aging process of bone. This longitudinal study examines the impact of continuous local and paracrine exposure to senescence-associated secretory phenotype (SASP) factors on biophysical and biomolecular markers in osteocytes....

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PMID: 40026102
DOI: 10.1002/smll.202408517

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