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A small lipidated peptide targeting Na <sub>V</sub> 1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion

2025-02-01

Abstract excerpt

Chronic pain is a major concern for patients with osteoarthritis (OA). Current treatments for OA-related pain often fail and may worsen the disease. The sodium channel subtype Na V 1.8 has emerged as a potential target for treating pain, leading to the development of Na V 1.8 inhibitors in clinical trials. We previously identified Magi-1, a WW domain-containing scaffold protein, as a regulator of Na V 1.8 at th...

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Literature Corpus work
8b0a15f5-1196-56ae-a6d3-eb278010e2aa
DOI
10.1101/2025.01.28.635324
Open publication

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A small lipidated peptide targeting Na <sub>V</sub> 1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosionDOI 10.1101/2025.01.28.635324
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