Article

<i>PIEZO1</i> variants that reduce open channel probability are associated with familial osteoarthritis

2024-09-05

Abstract excerpt

The synovial joints senses and responds to a multitude of physical forces to maintain joint homeostasis. Disruption of joint homeostasis results in development of osteoarthritis (OA), a disease characterized by loss of joint space, degeneration of articular cartilage, remodeling of bone and other joint tissues, low-grade inflammation, and pain. How changes in mechanosensing in the joint contribute to OA susceptibi...

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Literature Corpus work: 0a7d18c9-cc3a-5182-a8db-c924f69b01c4
DOI: 10.1101/2024.09.03.24312969

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