Article

Inhibiting nociceptor endocytosis reduces MIA-induced osteoarthritic pain behavior

2026-08-26

Abstract excerpt

<h4>Introduction: </h4> Osteoarthritis (OA) is a degenerative joint condition characterized by chronic pain and the need for pain management. Locally targeting the endocytotic AP2 complex in nociceptors presents a potential strategy for providing sustained pain relief in individuals with OA. <h4>Objective:</h4> We investigated whether pain behavior associated with OA can be mitigated by genetically silencing the A...

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Literature Corpus work: aed11477-09f5-58e5-9ff3-a0f074d5e4e3
DOI: 10.64898/2026.08.21.746311

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