Article

Unlocking Pain Therapeutics: How to Find the Right Target and Treatment Approach

2026-02-25

Abstract excerpt

The approval of the selective NaV1.8 inhibitor Suzetrigine for acute pain has renewed optimism for developing novel analgesics, yet the clinical failure of its successor VX993 highlights the persistent difficulty of translating promising pain targets into effective therapies. This review examines why progress has been limited and how modern human centered approaches can reshape pain drug discovery. Human genetic s...

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Literature Corpus work: 304fab1e-fc42-555f-bedf-01bf533f8196
DOI: 10.20944/preprints202602.1629.v1

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