Article

Leptin drives osteoarthritis pain through sensory neuron reprogramming independent of cartilage signaling

2026-06-09

Abstract excerpt

<h4>Objective</h4> Pain in osteoarthritis (OA) is often discordant with structural joint damage, particularly in obesity-associated OA, where adipose-derived signals may drive nociception independently of cartilage pathology. Leptin has been demonstrated to be necessary, but not sufficient, to drive obesity-associated OA. Here, we tested the hypothesis that leptin mediates OA-associated pain through sensory neuro...

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Literature Corpus work: a0aaea80-0ce8-57fb-beb3-b48f5dd104b0
DOI: 10.64898/2026.05.22.727205

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