Article

Two distinct mechanisms for Na <sub>v</sub> 1.7 null analgesia

2024-02-12

Abstract excerpt

Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain mechanisms, identifying targets and developing new analgesics. Both approaches have been applied to the voltage-gated sodium channels Na v 1.7 and Na v 1.8. Genetic deletion of Na v 1.8 in mice leads to a loss of pain, and antagonists are effective analgesics. Complete embryonic loss of Na v 1.7 in humans or in mouse se...

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Literature Corpus work: fef63c10-1c62-5f07-a0f5-491b505f6b11
DOI: 10.1101/2024.02.12.579826

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