Article

EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis

2025-01-22

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for H3K27 trimethylation, has emerged as a potential therapeutic target in osteoarthritis (OA). However, its contribution to the multicellular mechanisms driving joint degeneration and pain remains poorly understood. Here, we investigated the effects of pharmacological EZH2 inhibition in a pain-relevant murine OA model and explored its cel...

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Literature Corpus work: f7974790-22d3-5381-9203-933cfa8e6a9a
DOI: 10.1101/2025.01.19.633762

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