Article

Expanded gene targeting in RNA hacking with G-tract-supply Staple oligomer

2025-06-20

Abstract excerpt

RNA hacking (RNAh) is a gene regulation technology that employs a short oligonucleotide, termed a Staple oligomer, to induce the formation of RNA G-quadruplex structures on target mRNAs. While RNAh has the potential to target approximately 65% of human mRNAs, its applicability to the remaining genes is restricted by the sequence constraints. Herein, we present the G-tract-supply Staple oligomer (Gs-Staple oligomer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa8c2a8d-3ad6-5938-b3bb-76c10b3c2472
DOI: 10.1101/2025.06.17.660051

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expanded gene targeting in RNA hacking with G-tract-supply Staple oligomerDOI 10.1101/2025.06.17.660051Read

Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development TherapeuticsSemantic proximity Read

Programmable translational inhibition by a molecular glue-oligonucleotide conjugateSemantic proximity Read

Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic FrontiersSemantic proximity Read

Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.Semantic proximity Read

Orthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array.Semantic proximity Read

The Versatile Applications of Antisense Oligonucleotides in Modern MedicineSemantic proximity Read

Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugateSemantic proximity Read

Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcriptsSemantic proximity Read

RNA G-quadruplexes: emerging mechanisms in disease.Semantic proximity Read

rG4-seq 2.0: enhanced transcriptome-wide RNA G-quadruplex structure sequencing for low RNA input samplesSemantic proximity Read

A generative framework for enhanced cell-type specificity in rationally designed mRNAsSemantic proximity Read

Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug DevelopmentSemantic proximity Read