Article

Programmable translational inhibition by a molecular glue-oligonucleotide conjugate

2025-07-16

Abstract excerpt

Selective inhibition of mRNA translation is a promising strategy for modulating the activity of disease-associated genes, yet achieving both high potency and specificity remains challenging. Rocaglamide A (RocA), a molecular glue, inhibits translation by clamping eIF4A onto polypurine motifs found in many transcripts, thereby limiting RocA’s specificity. Here, we developed RocASO, a chemical conjugate that links R...

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Literature Corpus work: 0c63bc3e-4015-53f8-b1d2-16b7c4a082a1
DOI: 10.1101/2025.07.15.664547

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