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Article

Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.

Annals of the rheumatic diseases - 1 Aug 2021

Steinberg Julia, Southam Lorraine, Fontalis Andreas, Clark Matthew J, Jayasuriya Raveen L, Swift Diane, Shah Karan M, Brooks Roger A, McCaskie Andrew W, Wilkinson Jeremy Mark, Zeggini Eleftheria

Abstract excerpt

OBJECTIVES: To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm. METHODS: We analysed RNA sequencing data from cartilage and synovium in 113 osteoarthritis patients, applying unsupervised clustering and Multi-Omics Factor Analysis to characterise transcriptional...

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Share to Blood Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33903094
DOI: 10.1136/annrheumdis-2020-219760
PMCID: PMC8292595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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