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Article

Sex-specific DNA methylation differences in Alzheimer’s disease pathology

26 Apr 2021

Abstract excerpt

Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer's disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigenetic modification that regulates gene transcription and is known to be involved in AD. We performed the first large-scale sex-specific meta-analysis of DNA...

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PMID: 33902726
DOI: 10.1186/s40478-021-01177-8

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