Article

Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic mice

2022-09-26

Abstract excerpt

<h4>Objective</h4> Platelets for transfusion are stored for 5-7 days. During storage, platelets undergo numerous detrimental functional changes. In the current study, we sought to understand how genetic deletion of 12 –lipoxygenase (12-LOX) affects platelets during storage, before, and after transfusion. <h4>Approach and Results</h4> We obtained platelets from wild-type (WT) and 12-LOX-/-mice and performed stora...

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Identifiers and source

Literature Corpus work: 8ad5663e-5e28-5ad8-9acc-38671e2aeb26
DOI: 10.1101/2022.09.23.509265

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