Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Chen Wenchun, Liang Xin, Syed Anum K, Jessup Paula, Church William R, Ware Jerry, Josephson Cassandra D, Li Renhao

Abstract excerpt

OBJECTIVE: The platelet storage lesion accelerates platelet clearance after transfusion, but the underlying molecular mechanism remains elusive. Although inhibiting sheddase activity hampers clearance of platelets with storage lesion, the target platelet protein responsible for ectodomain shedding-induced clearance is not definitively identified. Monoclonal antibody 5G6 was developed recently to bind specifically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Component Removal
Share to Blood Platelets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Degranulation

Share to Hemostasis

Share to Immunoglobulin Fab Fragments

Share to Platelet Aggregation

Share to Platelet Glycoprotein GPIb-IX Complex

Share to Platelet Transfusion

Source

Open in PubMed Open full text

Identifiers

PMID: 27417583
DOI: 10.1161/ATVBAHA.116.307639
PMCID: PMC5001887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage.PMID 27417583Read ↗

Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic miceSemantic proximity Read ↗

Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets.Semantic proximity Read ↗

Thrombocytopathy leading to impaired in vivo haemostasis and thrombosis in platelet type von Willebrand disease.Semantic proximity Read ↗

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.Semantic proximity Read ↗

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-BSemantic proximity Read ↗

Proteomics-wise, how similar are mouse and human platelets?Semantic proximity Read ↗

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.Semantic proximity Read ↗

C560Rβ3 caused platelet integrin αII b β3 to bind fibrinogen continuously, but resulted in a severe bleeding syndrome and increased murine mortality.Semantic proximity Read ↗

Evaluation of amotosalem treated platelets over 7 days of storage with an automated cytometry assay panel.Semantic proximity Read ↗

Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopeniaSemantic proximity Read ↗

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?Semantic proximity Read ↗

An αIIb β3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.