Article

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

2023-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Lipids contribute to hematopoiesis and membrane properties and dynamics, however, little is known about the role of lipids in megakaryopoiesis. Here, a lipidomic analysis of megakaryocyte progenitors, megakaryocytes, and platelets revealed a unique lipidome progressively enriched in polyunsaturated fatty acid (PUFA)-containing phospholipids. In vitro, inhibition of both exogenous fatty acid func...

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Literature Corpus work: b59d84aa-91eb-5061-95e0-acc89323ff4e
DOI: 10.1101/2023.02.12.527706

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