Article
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Blood - 12 Jul 2018
Pleines Irina, Lebois Marion, Gangatirkar Pradnya, Au Amanda E, Lane Rachael M, Henley Katya J, Kauppi Maria, Corbin Jason, Cannon Ping, Bernardini Jonathan, Alwis Imala, Jarman Kate E, Ellis Sarah, Metcalf Donald, Jackson Shaun P, Schoenwaelder Simone M, Kile Benjamin T, Josefsson Emma C
Abstract excerpt
The circulating life span of blood platelets is regulated by the prosurvival protein BCL-XL It restrains the activity of BAK and BAX, the essential prodeath mediators of intrinsic apoptosis. Disabling the platelet intrinsic apoptotic pathway in mice by deleting BAK and BAX results in a doubling of platelet life span and concomitant thrombocytosis. Apoptotic platelets expose phosphatidylserine (PS) via a mechanism...
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