Article

Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritis

2025-03-27

Abstract excerpt

<h4>Background</h4> Rheumatoid arthritis (RA) is associated with significantly higher thrombotic risk, which is not yet mechanistically understood. Here, the role of pro-coagulant membranes of platelets and blood cells in driving thrombosis, and their regulation by inflammation was determined using human cohorts and genetically-modified mice. <h4>Methods</h4> Antigen-induced arthritis (AIA) was induced in WT, I...

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Literature Corpus work: d98e109f-2ca2-5479-950d-eec26c83a2a5
DOI: 10.1101/2025.03.26.645440

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Interleukin-6 elevates thrombosis via pro-coagulant phospholipids from platelet 12-lipoxygenase in rheumatoid arthritisDOI 10.1101/2025.03.26.645440Read

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