Article

Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

2024-12-13

Abstract excerpt

Biogenesis of circular RNA usually involves a backsplicing reaction where the downstream donor site is ligated to the upstream acceptor site by the spliceosome. For this reaction to occur, it is hypothesized that these sites must be in proximity. Inverted repeat sequences, such as Alu elements, in the upstream and downstream introns are predicted to base-pair and represent one mechanism for inducing proximity. Her...

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Literature Corpus work: 8accb0f8-b1f1-570c-9b80-6d8e5c8ea8f2
DOI: 10.1101/2024.12.13.628372

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