Article

The Chromosomal-Boundary Paradox of Processed Pseudogene Annotation in the T2T Era

2025-11-11

Abstract excerpt

<title>Abstract</title> <p>Background: Processed pseudogenes arise through LINE-1–mediated reverse transcription and reintegration of mRNA, a mechanism increasingly recognized as a major force shaping gene evolution. Far from being inert genomic debris, these retrocopies have contributed to gene diversification and regulatory innovation across mammalian lineages. With the completion of telomere-to-telomere (T2T)...

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Literature Corpus work: 96aaecba-4c93-5fcb-8c24-2e492230970f
DOI: 10.21203/rs.3.rs-7991770/v1

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