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Histone demethylase KDM5B is a key regulator of genome stability

28 Apr 2014

Abstract excerpt

Maintenance of genomic stability is essential for normal organismal development and is vital to prevent diseases such as cancer. As genetic information is packaged into chromatin, it has become increasingly clear that the chromatin environment plays an important role in DNA damage response. However, how DNA repair is controlled by epigenetic mechanisms is not fully understood. Here we report the identification...

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PMID: 24778210
DOI: 10.1073/pnas.1324036111

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