Article

Biochemical activity induced by a germline variation in KLK3 (PSA) associates with cellular function and clinical outcome in prostate cancer

2023-03-28

Abstract excerpt

<title>Abstract</title> <p>Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility. The non-synonymous KLK3 SNP, rs17632542 (c.536T>C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity as a previously undescribed function med...

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Literature Corpus work: 8abdfcba-3304-5a4d-b41b-9c8acaf3373b
DOI: 10.21203/rs.3.rs-2650312/v1

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