Article

Prostate cancer risk-stratification using proteomic estimation of KLK3 improves accuracy in screening applications: a population-based cohort study in the UK Biobank

2025-08-21

Abstract excerpt

<h4>Background</h4> The prostate specific antigen (PSA) test is the most used clinical tool for prostate cancer risk stratification. PSA-based screening remains controversial due to modest predictive power (ROC AUC<0.75), high false-positive rates and racial disparities. Here, we evaluated the prostate cancer risk-stratification potential for the KLK3 protein, measured by Olink® Explore-3072, in the UK Biobank. <...

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Literature Corpus work: 37d1199c-5536-5954-afc2-c50320aa5963
DOI: 10.1101/2025.08.21.25334151

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