Article
Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript.
Human genetics - 1 Jun 2011
Kote-Jarai Z, Amin Al Olama A, Leongamornlert D, Tymrakiewicz M, Saunders E, Guy M, Giles G G, Severi G, Southey M, Hopper J L, Sit K C, Harris J M, Batra J, Spurdle A B, Clements J A, Hamdy F, Neal D, Donovan J, Muir K, Pharoah P D P, Chanock S J, Brown N, Benlloch S, Castro E, Mahmud N, O'Brien L, Hall A, Sawyer E, Wilkinson R, Easton D F, Eeles R A
Abstract excerpt
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate susceptibility gene, KLK3, which encodes prostate-specific antigen (PSA). PSA is widely used as a biomarker for PrCa detection and disease monitoring. To refine the association between PrCa and variants in this region, we used genotyping...
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