Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.

doi:10.1007/s00439-011-0953-5

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Article

Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.

Human genetics - 1 Jun 2011

Parikh Hemang, Wang Zhaoming, Pettigrew Kerry A, Jia Jinping, Daugherty Sarah, Yeager Meredith, Jacobs Kevin B, Hutchinson Amy, Burdett Laura, Cullen Michael, Qi Liqun, Boland Joseph, Collins Irene, Albert Thomas J, Vatten Lars J, Hveem Kristian, Njølstad Inger, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Virtamo Jarmo, Thun Michael J, Feigelson Heather Spencer, Diver W Ryan, Chatterjee Nilanjan, Thomas Gilles, Albanes Demetrius, Chanock Stephen J, Hunter David J, Hoover Robert, Hayes Richard B, Berndt Sonja I, Sampson Joshua, Amundadottir Laufey

Abstract excerpt

Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine mapped this locus...

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Identifiers

PMID: 21318478
DOI: 10.1007/s00439-011-0953-5
PMCID: PMC3092924

Genes

KLK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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