Article
Very low PSA concentrations and deletions of the KLK3 gene.
Clinical chemistry - 1 Jan 2013
Rodriguez Santiago, Al-Ghamdi Osama A, Burrows Kimberley, Guthrie Philip A I, Lane J Athene, Davis Michael, Marsden Gemma, Alharbi Khalid K, Cox Angela, Hamdy Freddie C, Neal David E, Donovan Jenny L, Day Ian N M
Abstract excerpt
BACKGROUND: Prostate-specific antigen (PSA), a widely used biomarker for prostate cancer (PCa), is encoded by a kallikrein gene (KLK3, kallikrein-related peptidase 3). Serum PSA concentrations vary in the population, with PCa patients generally showing higher PSA concentrations than control individuals, although a small proportion of individuals in the population display very low PSA concentrations. We...
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