Article
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer.
Nature communications - 6 Nov 2024
Srinivasan Srilakshmi, Kryza Thomas, Bock Nathalie, Tse Brian W C, Sokolowski Kamil A, Janaththani Panchadsaram, Fernando Achala, Moya Leire, Stephens Carson, Dong Ying, Röhl Joan, Alinezhad Saeid, Vela Ian, Perry-Keene Joanna L, Buzacott Katie, Nica Robert, Gago-Dominguez Manuela, Schleutker Johanna, Maier Christiane, Muir Kenneth, Tangen Catherine M, Gronberg Henrik, Pashayan Nora, Albanes Demetrius, Wolk Alicja, Stanford Janet L, Berndt Sonja I, Mucci Lorelei A, Koutros Stella, Cussenot Olivier, Sorensen Karina Dalsgaard, Grindedal Eli Marie, Travis Ruth C, Haiman Christopher A, MacInnis Robert J, Vega Ana, Wiklund Fredrik, Neal David E, Kogevinas Manolis, Penney Kathryn L, Nordestgaard Børge G, Brenner Hermann, John Esther M, Gamulin Marija, Claessens Frank, Melander Olle, Dahlin Anders, Stattin Pär, Hallmans Göran, Häggström Christel, Johansson Robert, Thysell Elin, Rönn Ann-Charlotte, Li Weiqiang, Brown Nigel, Dimeski Goce, Shepherd Benjamin, Dadaev Tokhir, Brook Mark N, Spurdle Amanda B, Stenman Ulf-Håkan, Koistinen Hannu, Kote-Jarai Zsofia, Klein Robert J, Lilja Hans, Ecker Rupert C, Eeles Rosalind, Clements Judith, Batra Jyotsna
Abstract excerpt
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer...
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