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Article

Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.

Carcinogenesis - 1 Jun 2011

Penney Kathryn L, Schumacher Fredrick R, Kraft Peter, Mucci Lorelei A, Sesso Howard D, Ma Jing, Niu Yuxin, Cheong Jit Kong, Hunter David J, Stampfer Meir J, Hsu Stephen I

Abstract excerpt

Genome-wide association studies have identified genetic markers in kallikrein-related peptidase 3 (KLK3) associated with prostate cancer. However, some of these markers are also associated with prostate-specific antigen (PSA) levels, so it is unclear whether the polymorphisms are causal or if the association with risk is solely due to detection bias through PSA screening. PSA is a biologically active serine...

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Identifiers

PMID: 21421545
DOI: 10.1093/carcin/bgr050
PMCID: PMC3106437

Genes

KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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