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Article

Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen.

BMC biology - 17 Dec 2025

Srinivasan Srilakshmi, Hayes Brooke K, Costa Mauricio G S, Riley Blake T, Wilson Emily, Marijanovic Emilia M, Kass Itamar, Koistinen Hannu, Hoke David E, Clements Judith, Buckle Ashley M, Batra Jyotsna

Abstract excerpt

BACKGROUND: Two non-synonymous single-nucleotide polymorphisms (SNPs) rs61752561 (D95N substitution) and rs17632542 (I163T substitution) in the KLK3 gene encoding prostate-specific antigen (PSA), a chymotrypsin-like serine protease, are associated with prostate cancer risk and have been shown to reduce the activity of PSA. However, the structural impact of these SNPs on PSA, which may underlie the observed risk...

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Source

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Identifiers

PMID: 41402853
DOI: 10.1186/s12915-025-02458-7
PMCID: PMC12821267

Genes

KLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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