Article

Segregating DNA lesions point to high selective advantage of tumor initiating cells

2025-10-04

Abstract excerpt

The complications with identifying cells at the origin of cancer and tracking their early divisions impede studies of cancer initiation. Recently, it was shown that some DNA lesions generated by a pulse of damage-inducing mutagen persist over multiple rounds of replication. Segregation of DNA lesions in the early genealogy of an expanding clone leaves a statistically interpretable footprint of cancer initiating ev...

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Literature Corpus work: 67060770-754a-5fd0-bf9a-f0932d37345c
DOI: 10.1101/2025.10.02.680094

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